Molecular Development of Placenta and Its Relationship with Preeclampsia and Fetal Growth Restriction

Preeclampsia (PE) is the leading causes of maternal death worldwide as well a significant cause fetal morbidity and mortality, including growth restriction (FGR). The concept that PE FGR shared common etiology widely accepted, i.e., maladaptive response to impaired placentation. Normal placentation result dynamic integration cell proliferation, differentiation, migration, in which trophoblast cells play crucial role. Impaired invasion into decidua leads decrease uteroplacental blood flow changes intervillous hemodynamic. interaction these process with decidual immune response, cytokines angiogenic factors regulation, oxidative stress will lead clinical manifestation and/or FGR.